Prof. Philippe Mathurin
CURRICULUM VITAE OF PHILIPPE MATHURIN
Born on November 30 1962 at Saint-Claude Guadeloupe
Maried, three children
Phone : 33 320445597; Fax : 33320445564. Email : [email protected]
N° du conseil de l’ordre : 59/17538
HOSPITAL DEGREES
– Resident of Paris Hospital 1987-1993
– Fellowship in hepatology of Paris Hospital, 1993-1996, Unit of Hepatogastroenterology, Pr Opolon, Pitié-Salpêtrière Hospital
– Assitant professor 1997-1999, Bléclère Hospital,
– Professor of Medicine (speciality Hépatology and Gastroenterology) 2003; Service MAD Hôpital Huriez 1er étage Est Avenue Michel Polonovski CHRU Lille 59037;
UNIVERSITY DEGREES
– Ph D 2002
– Medical Doctor Faculté de Médecine Paris-Sud ; speciality hepatogastroenterology 1993
– DEA of cellular biology in gastrointestinal process 1992
– Mastership of molecular biology (University of Paris V) 1991
– Concourse of Resident of Medicine 1987 – Concourse of Medicine (University of Saint-Antoine) 1981
AFFILIATIONS
– Services des Maladies de l’appareil Digestif, Hôpital Claude Huriez, CHRU Lille; Inserm U 795 ; Univ Lille 2
SCIENTIFIC SOCIETIES
– Member of the Société Française Nationale de Gastroentérologie, 1995 and of the Association Française de l’Etude du Foie (AFEF),1994
– Member of the EASL
– Member of AASLD
– Associate editor of Journal of Hepatology since 2009
RESEARCH
– Researcher in the unit of URA CNRS 1484 from 1991 to 1994), in the laboratory of Pr. Hidekazu Tsukamoto, USC School of Medicine, Los Angeles, USA) from 1997 to 1999 and in the Inserm U995 from 2002
PUBLICATIONS
More than 180 communications and publications since 1991
Selection of main publications
Ramond Mj, Poynard T, Rueff B, Mathurin P, Theodore C, Chaput Jc, Benhamou Jp. A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med 1992;326:507-512.
Mathurin P, Vidaud D, Vidaud M, Bedossa P, Paradis V, Ratziu V, Chaput Jc, Poynard T. Quantification of apolopoprotein A-I (ApoA-I) and apolipoprotein B (ApoB) mRNA in heavy drinkers according to liver disease. Hepatology 1996, 23: 44-51.
Paradis V, Mathurin P, Ratziu V, Poynard T, Bedossa P. Binding of apolipoprotein A-I and acetaldehyde-modified apolipoprotein A-I to liver extracellular matrix. Hepatology 1996;23:1232-8.
Poynard T, Bedossa P, Chevallier M, Mathurin P, Lemonnier C, Trepo C, Couzigou P, Payen Jl, Sajus M, Costa Jm, Vidaud M, Chaput Jc And The Multicenter Study Group. A comparison of three interferon alpha-2b regimens for long-term treatment of chronic non-A, non-B hepatitis. N Eng J Med, 1995;332:1457-62.
Mathurin P, Duchatelle V, Ramond Mj, Degott C, Bedossa P, Erlinger S, Benhamou Jp, Chaput, Rueff B, Poynard T. Survival and prognostic factors in patients with severe biopsy-proven alcoholic hepatitis treated by prednisolone: randomized trial, new cohort, and simulation. Gastroenterology 1996, 110:1847-1853
Poynard T, Leroy V, Cohard M, Thevenot T, Mathurin P, Opolon P, Zarski JP. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C. Effects of dose and duration. Hepatology 1996; 24:778-89.
Bernard B, Lebrec D, Mathurin P, Poynard T. Beta-adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis : A meta-analysis. Hepatology 1997;25: 63-70.
Mathurin P, Moussalli J, Cadranel Jf, Thibault V, Charlotte F, Dumouchel P, Cazier A, Huraux Jm, Devergie B,Vidaud M, Opolon P, Poynard T.Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminases activity. Hepatology 1998;27:868-72.
Sobesky R, Mathurin P, Charlotte F, Moussalli J, Olivi M, Vidaud M, Ratziu V, Opolon P, Poynard T. Modeling the impact of alfa interferon treatment on the natural history of liver fibrosis progression in patients with chronic hepatitis C : a dynamic view. Gastroenterology 1999;116:378-86.
Mathurin P, Mouquet C, Poynard T, Sylla C, Benalia H, Fretz C, Bernard B, Charlotte F, Opolon P, Coriat P, Bitker MO. Impact of hepatitis B and C virus on kidney transplantation outcome. Hepatology 1999;29:257-63.
Mathurin P, Rixe O, Carbonel N, Cluzel P, Bernard B, Khayat D ,Opolon P, Poynard T. Overview of medical treatments in hepatocellular carcinoma : an impossible meta-analysis ? Aliment Pharmacol Ther 1998;12:111-26.
Mathurin P, Deng Qg,Kesharvazian A, Choudary S, Holmes Ew, Tsukamoto H. Exacerbation of alcoholic liver injury by enteral endotoxin loading . Hepatology 2000;32:1008-1017.
Taïeb J, Mathurin P, Elbim C, Cluzel P, Arce-Vicioso M, Bernard B, Opolon P, Gougerot-Pocidalo Ma, Poynard T, Chollet-Martin S. Blood neutrophil functions and cytokine synthesis in severe alcoholic hepatitis. Effect of corticosteroids. J Hepatol 2000; 32 :579-586.
Mathurin P, Mendenhall C, Carithers Rl Jr, Ramond Mj, Maddrey Wc5, Garstide P, Rueff B, Naveau S, Chaput Jc, Poynard T. Corticosteroids improve short term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials. J Hepatol 2002 ; 36 :480-487.
Mathurin P, Xiong S, Kharbanda Kk, Veal N, Miyahara T, Motomura K, Rippe Ra, Bachem Mg, Tsukamoto H. IL-10 receptor and co-receptor expression in quiescent and activated stellate cells. Am J Physiol Gastrointest Liver Physiol 2002;282:G981-G990.
Poynard T, Mathurin P, Lai Cl, Guyader D, Poupon R, Taiturier H, Muntenau M, Ratziu V, Capron D, Chedid A, Bedossa P. A comparison of fibrosis progression in chronic liver diseases. J Hepatol 2003; 38:256-265.
Mathurin P, Bruno Raynard, Sebastien Dharancy, Sylvain Kirzin, Fallik D, Pruvot FR, Canva V, Paris JC, Chaput JC, Naveau S. Evaluation of adjuvant therapy after curative liver resection for hepatocellular carcinoma: a meta-analysis. Aliment Pharmacol Ther 2003 ; 17:1247-61.
Mathurin P, Abdelnour M, Ramond MJ, Carbonnel N, Fartoux L, Serfaty L, Valla D, Poupon R, Chaput JC, Naveau S. Early biological response (EBR) is an important prognostic factor in severe biopsy-proven alcoholic hepatitis (AH) treated by prednisolone Hepatology 2003; 38: 1363-1369.
Deltenre P, Henrion J, Canva V, Texier F, Dharancy S, Louvet A, De Maeght S, Paris JC, Mathurin P. Evaluation of amantadine in chronic hepatitis C: a meta-analysis. J Hepatol 2004; 41: 462-473.
Mathurin P, Gonzalez F, Kerdraon O, Leteurtre E, Arnalsteen L, Cocq P, Hollebecque A, Dharancy S, Louvet A, Boitard J, Deltenre P, Pattou F. The evolution of severe steatosis after bariatric surgery is related to insulin resistance. Gastroenterology 2006; 130:1617-1624.
Mathurin P, Beuzin F, Louvet A, Carrié-Ganne N, Balian A, Trinchet JC, Dalsoglio D, Prevot S, Naveau S.Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features. Aliment Pharmacol Ther 2007; 25:1047-54.
Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, Dharancy S, Texier F, Hollebecque A, Serfaty L, Boleslawski E, Deltenre P, Canva V, Pruvot FR, Mathurin P. The lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis. Hepatology 2007; 45:1275-81.
Deuffic-Burban S, Deltenre P, Louvet A, Canva V, Dharancy S, Hollebecque A, Boitard J, Yazdanpanah Y, Mathurin P. Impact of viral eradication on mortality related to hepatitis C using a modeling approach. J Hepatol2008;49:175-83.
Louvet A, Diaz E, Dharancy S, Coevoet H, Texier F, Thévenot T, Deltenre D, Canva V, Plane C, Mathurin P. Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids. JHepatol2008;48:465-470.
Mathurin P, Deltenre P. Binge drinking is harmful for the liver: from experimental studies to clinical data. Gut 2009; 58: 613-7.
Mathurin P, Hollebecque A, Arnalsteen L, Caiazzo R, Leteurtre E, Buob D, Dharancy S, Louvet A, Romon M, Pattou F. Long-term effects of bariatric surgery upon liver injury: a prospective study. Gastroenterology 2009; 137:532–540.
Louvet A, Wartel F, Castel H, Dharancy S, Hollebecque A, Canva-Delcambre V, Deltenre P, Mathurin P. Prospective Screening Of Infection In Patients With Severe Alcoholic Hepatitis Treated With Steroids: Early Response To Therapy Is The Key Factor. Gastroenterology 2009; 137:541–548.
Dharancy S, Iannelli A, Hulin A, Declerck A , Schneck AS, Mathurin P, Boleslawski E, Gugenheim J, Pruvot FR. Mycophenolate mofetil monotherapy for severe side effects of calcineurin inhibitors following liver transplantation. American Journal of Transplantation 2009; 9: 610–613.
Deltenre P, Canva V, El Nady M, François C, Castelain S, Dharancy S, Louvet A, Bocket L, Lazrek M, Hollebecque A, Wartel F, Henrion J, Duverlie G, Mathurin P. A 2-log drop in viral load at 1 month is the best predictor of sustained viral response in patients with normal ALT: A kinetic prospective study. J Viral Hepatitis 2009; 16: 500-505.
Lucey MR, Mathurin P, Morgan TR.Alcoholic Hepatitis. N Engl J Med 2009; 360: 2758-2769.
Mathurin P, Deltenre P. Binge drinking is harmful for the liver: from experimental studies to clinical data. Gut 2009; 58: 613-7.
Deuffic-Burban S, Babany G, Lonjon-Domanec I, Deltenre P, Canva-Delcambre V, Dharancy S, Louvet A, Roudot-Thoraval F, Mathurin P. Impact of Pegylated Interferon and Ribavirin on morbidity and mortality in patients with chronic hepatitis C and normal transaminases. Hepatology 2009; 50:1351-1359.
Moreno C , Deltenre P, Pawlotsky JM, Henrion H, Adler M, Mathurin P.Shortened Treatment duration in treatment-naive genotype 1 HCV patients with rapid virological response: a meta-analysis. J Hepatol 2009; 52:25-31.
Dharancy S, Body-Malapel M, Louvet A, Berrebi D, Gantier E, Gosset P, Viala J, Hollebecque A, Moreno C, Philpott DJ, Girardin SE, Sansonetti PJ, Desreumaux P, Mathurin P, Dubuquoy L.Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control. Gastroenterology 2010;138:1546-1556.
Deltenre P, Corouge M, Canva V, Castel H, Wartel F, Dharancy S, Louvet A, Lazrek M, Moreno C, Henrion J, Mathurin P. sefulness of viral kinetics for early prediction of a sustained virological response in HCV-1 non-responders re-treated with pegylated interferon and ribavirin. J Hepatol 2011;52:25-31.
Mathurin P, O’Grady J, Carithers RL, Phillips M, Louvet A, Mendenhall CL, Ramond MJ, Naveau S, Maddrey WC, Morgan TR. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut 2011; 60:255-260.
Lassailly G, Caiazzo R, Hollebecque A, Buob D, Leteurtre E, Arnalsteen L, Louvet A, Pigeyre M, Raverdy V, Verkindt H, Six MF, Eberle C, Patrice A, Dharancy S, Romon M, Pattou F, Mathurin P. Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity. Eur J Gastroenterol Hepatol. 2011;23:499-506.
Ratziu V, de Ledinghen V, Oberti F, Mathurin P, Wartelle-Bladou C, Renou C, Sogni P, Maynard M, Larrey D, Serfaty L, Bonnefont-Rousselot D, Bastard JP, Rivière M, Spénard J; FRESGUN. A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis. J Hepatol. 2011;5:1011-9.
Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, Castel H, Duhamel A, Pageaux GP, Leroy V, Dharancy S, Louvet A, Boleslawski E, Lucidi V, Gustot T, Francoz C, Letoublon C, Castaing D, Belghiti J, Donckier V, Pruvot FR, Duclos-Vallee JC. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med, 2011; 365: 1790-800.
Poynard T, Lassailly G, Diaz E, Clement K, Caïazzo R, Tordjman J, Munteanu M, Perazzo H, Demol B, Callafe R, Pattou F, Charlotte F, Bedossa P, Mathurin P, Ratziu V; FLIP consortium. Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data. PLoS One. 2012;7 30325.
Deuffic-Burban S, Deltenre P, Buti M, Stroffolini T, Parkes J, Mühlberger N, Siebert U, Moreno C, Hatzakis A, Rosenberg W, Zeuzem S, Mathurin P.Predicted effects of treatment for HCV infection vary among European countries. Gastroenterology. 2012;143:974-85.
Lassailly G, Caïazzo R, Pattou F, Mathurin P. Bariatric surgery for curing NASH in the morbidly obese? J Hepatol. 2013;58:1249-1251.
Mathurin P, Louvet A, Duhamel A, Nahon P, Carbonell N, Boursier J, Anty R, Diaz E, Thabut D, Moirand R, Lebrec D, Moreno C, Talbodec N, Paupard T, Naveau S, Silvain C, Pageaux GP, Sobesky R, Canva-Delcambre V, Dharancy S, Salleron J, Dao T. JAMA. 2013;310:1033-1341.