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Newsletter May 2014

May 2014 – Newsletter


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Announcement: HIGH LEVEL MEETING Economic crisis and healthcare - ensuring access to public health services: the case of hepatitis B and C Athens, June 3-4 2014

High Level MeetingThe High-Level meeting is held under the auspices of the Greek EU Presidency, the Greek Ministry of Health and the Greek Ministry of Foreign Affairs. Mr. Adonis Georgiadis, Minister of Health of Greece and Chair of the Council of EU Health Ministers, will be a lead speaker. At a juncture where major therapeutical improvements become available, national policies taken under austerity programmes may not encourage the best public health outcomes. National responses to the spreading epidemic of hepatitis B and C provide a clear example of this situation. The High-Level Meeting will examine national approaches, debate new developments and identify public policies to facilitate and improve access to care and treatment for hepatitis B and hepatitis C even in countries where austerity programmes are in place. For further information please see the Meeting’s website on www.hepmeeting2014.org.

An interview with Professor Mario U. Mondelli, MD PhD FRCP President of the International Association for the Study of the Liver (IASL)

Q 1. Professor Mondelli, can you summarize the history of IASL?

Established in 1958, the International Association for the Study of the Liver (IASL) is among the oldest professional associations of clinicians and scientists dedicated to translating liver research into clinical practice. IASL works in concert with five continental constituent associations: the African Association for the Study of Liver Diseases (AFASLD), the American Association for the Study of Liver Diseases (AASLD), the Asian-Pacific Association for the Study of the Liver (APASL), the European Association for the Study of the Liver (EASL), the Asociación Latinoamericana para el Estudio del Hígado (ALEH). As such, IASL has a traditionally global view of liver disease worldwide. Past Presidents of IASL were high-profile personalities and founders of modern hepatology such as Hans Popper, Sheila Sherlock, James Boyer to cite but a few. Members of the Council are representatives of the constituent associations directly coopted by council members upon proposal from continental associations.

Q.2 What role do you envisage for the society in the coming years?

IASL used to hold independent scientific meetings until some 20 years ago when it became clear that continental associations, particularly AASLD, EASL and APASL, were expanding significantly (up to 10,000 delegates at each meeting) at the expense of IASL. Under my mandate as President, it was decided to change mission to focus predominantly on education, particularly in countries where hepatology is underdeveloped or does not exist even as a subspecialty of gastroenterology. After a successful postgraduate course held in 2012 in Paraguay, this process of transition is still going on. This year we are going to China where, despite the many resources available and the enormous number of patients with chronic liver disease, hepatology is still poorly developed. Other activities include meetings focused on global epidemiology of liver disease, access to care and public health issues. To this end, IASL recently co-organized a joint meeting with the International Association of providers of AIDS Care in New York City, in which issues related to access to the new HCV drugs have been extensively debated in  light of limited economic resources. Besides these activities IASL still continues to hold biennial scientific meetings in conjunction with the two major continental associations, EASL and AASLD. EASL and IASL met in London last month during the International Liver Congress where joint sessions were held.

Q.3 Do you think that IASL could play a role in broadening access to effective anti HBV and HCV treatments?

Indeed. IASL is a non-profit organization whose mission is to foster knowledge about prevention, diagnosis, and treatment of liver diseases. Therefore, every effort will be made to help achieving control of chronic liver disease worldwide. Viral hepatitis is a global public health problem and I am convinced that our association could play a pivotal role in this context. Eradication of HBV by 2020 has been declared a priority by WHO. Whether this will be possible in such a short time frame is uncertain and most probably unlikely. However, the dice is cast and hepatitis B vaccination is slowly being applied to the poorest countries in Africa and the Far East where the prevalence of chronic HBV infection and liver cancer is particularly high. Drugs to control complications of chronic HBV infection are also needed where the infection is endemic at a minimal cost. The successful example of DOTS (directly observed treatment, short-course) for tuberculosis should be taken as an example of great success in the face of limited investment. After achieving control of complications research efforts should be concentrated on new treatments to eradicate occult HBV infection. HCV treatment is in full swing now with 2nd generation directly acting antivirals (DAAs) promising an outstanding 90-100% success rate. Problems include enormous costs, often in excess of $100,000 per treatment, and disparity between potential HCV treatment efficacy and projected HCV treatment effectiveness. There are hints that the former problem can be reconsidered by negotiating drug prices with the big pharmas and the example of Egypt obtaining a 99% discount rate for sofosbuvir gives hope that this can at least partially be solved. With respect to the latter, the lack of expanded HCV testing will have no impact on unrecognized HCV infection. To this end, IASL could play a major role through education and promotion of HCV serology testing in high-risk cohorts such as baby boomers in the US to identify asymptomatic patients in need of treatment.

Professor Mario U. Mondelli MD PhD FRCP

Department of Internal Medicine University of Pavia

Director, Research Laboratories, Department of Infectious Diseases,

Fondazione IRCCS Policlinico San Matteo via Taramelli 5, 27100, Pavia, Italy

e-mail: mario.mondelli@unipv.it

The interview was conducted by

Alessio Aghemo, MD PhD 1st Division of Gastroenterology Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico University of Milan, Italy

Announcement: The Viral Hepatitis Congress 2014, 9-11 October Frankfurt, Germany

Viral Hepatitis Congress Logo

This year the third Viral Hepatitis Congress will take place from Thursday 9 October to Saturday 11 October at the Sheraton Frankfurt Airport Hotel & Conference Center. The venue offers the full range of facilities for Congress participants and, as the Congress Center is directly connected to the main airport terminal, it is incredibly easy to get to and from the meeting. The 2013 meeting was once again judged to provide a high-quality and relevant scientific programme, augmented by extremely popular, innovative and interactive discussion sessions. We are confident that, by continuing to engage a world-class faculty, this year’s meeting will be even better. 2014 will see great changes in the field of viral hepatitis, with many drugs arriving and various treatment options for patients. In this rapidly evolving environment, it is more important than ever to sustain a forum where the wealth of data can be put into a practical perspective for physicians. The Viral Hepatitis Congress will digest the latest data from a broad range of sources, examine the new treatments, and translate this array of information for our audience. The cutting-edge programme will explore the clinical challenges presented by viral hepatitis infection and its associated complications. There will be a particular focus on the latest developments and innovations in the practical aspects of disease management all of which are presented in a single track plenary sessions so congress delegates do not miss out.  This interactive and engaging meeting is made up of the following elements:

o   Keynote lectures and invited presentations by world leaders in the treatment of viral hepatitis, including the following special opening lecture:

o   Keeping blood safe – a global challenge Harvey J Alter (NIH, USA)

o   Plenary and poster sessions exploring and discussing the latest clinical data, including:

o   Viral hepatitis A, B, C, D, and E

o   Comorbidities, such as HIV infection

o   Hepatocellular carcinoma

o   Clinical case studies

o   Discussion and Q&A sessions, enhanced by cutting-edge, interactive keypads

o   Oral and poster communications

o   Industry sessions and pre-Congress workshops

o   Vibrant exhibition in the main Congress hall.

The Congress scientific committee and faculty continue to include experts from across Europe, the USA and Canada, offering delegates the chance to discuss clinical experiences and key knowledge with the leading authorities in the viral hepatitis field. In order to broaden the reach of the Congress and bridge the gap to the virtual audience, we will continue to engage with our online community by a number of means:

o   Abstracts will be published as a supplement to the Journal of Viral Hepatitis

o   Interviews with faculty will be available on a dedicated YouTube channel: ViralHepatitisTV

o   We will be operating a fully integrated social media campaign to enable our online audience to interact and keep up-to-date with news both before, during and after the congress

o   Speakers’ presentations will be recorded and webcast on www.viral-hep.org

o   >Posters presented at the Congress will be brought together as online, interactive books.

In this fast-moving and highly exciting era for hepatitis treatment, the opportunity to network and actively participate in the debate and discussion is a key component of the Congress, further enhancing the learning experience. Networking opportunities include the opening-night welcome reception and a lively poster and exhibition area directly outside the main auditorium, and immersive participation will be guaranteed by utilising a cutting-edge audience response system that allows audience voting, direct text questions, verbal discussion and ‘real time’ feedback. In summary, our focus is to provide improved network opportunities, a unique and specialised learning atmosphere and a truly individualised participant experience. For more information and the latest updates on The Viral Hepatitis Congress 2014, visit www.viral-hep.org or contact the organising secretariat. Congress registration is open until 30 September 2014.   Enquiries to: The Viral Hepatitis Congress, Organising Secretariat: hep@kp360group.com

A report from APASL Brisbane 2014
The sixth international conference “White Nights of Hepatology” June 5th & 6th, St Petersburg, Russia

Enquiries to: Corporate Secretary, Hepatitis B & C Public Policy Association asbl